Protocols & Procedures

This section contains the essential information used in conducting the CALERIE^TM Study. It includes documents detailing  the aims of the study,  screening of participants, and follow-up procedures. These documents will assist Network Investigators in understanding the details of the interventions and conditions under which study assessments, data, and samples were collected.

• Manual of Procedures - 28 sections with logistical details of the trial
• Phase 2 Protocol - 113-page annotated text used in regulatory documents describing the study 
• Pennington Muscle & Adipose Biopsy MOP/SOP - Detailed description of the procedures used to obtain muscle and adipose tissue biopsies. 
• CALERIE Standard Analysis R Notebook - This is a customizable R markdown notebook file that implements the standard CALERIE analysis approach